Leeds beat Wolves 3-0 on Saturday to pull clear of the bottom three.
Brighton's equaliser in their 2-2 draw with Tottenham later in the day saved Wolves from being officially relegated.
But their eight-year stay in the top flight is coming to an end as Leeds opened up an eight-point cushion on the bottom three.
Fresh from a first league win away at fierce rivals Manchester United since 1981, Leeds all but secured their top-flight status.
Two goals in two first-half minutes from James Justin and Noah Okafor put the home side in control before Dominic Calvert-Lewin's penalty in stoppage time rounded off the scoring.
Eighteenth-placed Tottenham's woeful campaign has been compounded by an impressive return to the top flight by Sunderland and Leeds, to buck the trend of recent seasons.
For the past two years all three promoted sides have gone straight back down.
However, Daniel Farke's men not only look set for survival, but could reach a first FA Cup final since 1973 should they beat Chelsea in next weekend's semi-finals.
