Oklahoma running back Samaje Perine went to the locker room in the second quarter of Saturday's contest versus Kansas State with an apparent injury.
Perine spent part of the second quarter limping around the sidelines and being checked on by trainers before leaving with about three minutes remaining in the half.
Perine, who's been hobbled by lower-body injuries throughout his Sooners career, entered the day with 461 rushing yards and six touchdowns for the season.
He caught his first touchdown reception of the year before exiting Saturday's contest.