49ers' full 2021 regular-season schedule
Adam Glanzman / Getty Images Sport / Getty
The NFL announced its complete 2021 regular-season schedule Wednesday. See below for matchups, dates, and start times for the San Francisco 49ers.
| Week | Opponent | Date | Time (ET) |
|---|---|---|---|
| 1 | at Lions | Sept. 12 | 1 p.m. |
| 2 | at Eagles | Sept. 19 | 1 p.m. |
| 3 | vs. Packers | Sept. 26 (SNF) | 8:20 p.m. |
| 4 | vs. Seahawks | Oct. 3 | 4:05 p.m. |
| 5 | at Cardinals | Oct. 10 | 4:25 p.m. |
| 6 | Bye | - | - |
| 7 | vs. Colts | Oct. 24 (SNF) | 8:20 p.m. |
| 8 | at Bears | Oct. 31 | 1 p.m. |
| 9 | vs. Cardinals | Nov. 7 | 4:25 p.m. |
| 10 | vs. Rams | Nov. 15 (MNF) | 8:15 p.m. |
| 11 | at Jaguars | Nov. 21 | 1 p.m. |
| 12 | vs. Vikings | Nov. 28 | 4:25 p.m. |
| 13 | at Seahawks | Dec. 5 (SNF) | 8:20 p.m. |
| 14 | at Bengals | Dec 12 | 1 p.m. |
| 15 | vs. Falcons | Dec. 19 | 4:05 p.m. |
| 16 | at Titans | Dec. 23 (TNF) | 8:20 p.m. |
| 17 | vs. Texans | Jan. 2 | 4:05 p.m. |
| 18 | at Rams | Jan. 9 | 4:25 p.m. |
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