Samuel out, Aiyuk questionable vs. Cardinals

The San Francisco 49ers will be shorthanded at receiver when they take on the Arizona Cardinals on Sunday.

The team ruled wideout Deebo Samuel out for Week 1 due to a foot injury, and rookie wideout Brandon Aiyuk is questionable with a hamstring ailment.

Samuel has been pressing hard to be available for the regular season after suffering a broken left foot in June. In August, head coach Kyle Shanahan expressed optimism that his top wideout would be available for the season opener, but Samuel didn't practice all week.

Aiyuk didn't practice Wednesday and was limited on Thursday and Friday. Should he be unavailable Sunday, the 49ers would be down its leading receiver from a season ago and their second first-round pick in this year's draft.

The receiving corps would be led by All-Pro tight end George Kittle, and wideouts Kendrick Bourne, Dante Pettis, Trent Taylor, and Richie James.