The NFL announced its complete 2021 regular-season schedule Wednesday. See below for matchups, dates, and start times for the Carolina Panthers.
| Week | Opponent | Date | Time (ET) |
|---|---|---|---|
| 1 | vs. Jets | Sept. 12 | 1 p.m. |
| 2 | vs. Saints | Sept. 19 | 1 p.m. |
| 3 | at Texans | Sept. 23 (TNF) | 8:20 p.m. |
| 4 | at Cowboys | Oct. 3 | 1 p.m. |
| 5 | vs. Eagles | Oct. 10 | 1 p.m. |
| 6 | vs. Vikings | Oct. 17 | 1 p.m. |
| 7 | at Giants | Oct. 24 | 1 p.m. |
| 8 | at Falcons | Oct. 31 | 1 p.m. |
| 9 | vs. Patriots | Nov. 7 | 1 p.m. |
| 10 | at Cardinals | Nov. 14 | 4:05 p.m. |
| 11 | vs. Washington | Nov. 21 | 1 p.m. |
| 12 | at Dolphins | Nov. 28 | 1 p.m. |
| 13 | Bye | - | - |
| 14 | vs. Falcons | Dec. 12 | 1 p.m. |
| 15 | at Bills | Dec. 18/19 | TBD |
| 16 | vs. Buccaneers | Dec. 26 | 1 p.m. |
| 17 | at Saints | Jan. 2 | 1 p.m. |
| 18 | at Buccaneers | Jan. 9 | 1 p.m. |
