The NFL announced its complete 2021 regular-season schedule Wednesday. See below for matchups, dates, and start times for the Jacksonville Jaguars.
| Week | Opponent | Date | Time (ET) |
|---|---|---|---|
| 1 | at Texans | Sept. 12 | 1 p.m. |
| 2 | vs. Broncos | Sept. 19 | 1 p.m. |
| 3 | vs. Cardinals | Sept. 26 | 1 p.m. |
| 4 | at Bengals | Sept. 30 (TNF) | 8:20 p.m. |
| 5 | vs. Titans | Oct. 10 | 1 p.m. |
| 6 | vs. Dolphins | Oct. 17 (London) | 9:30 a.m. |
| 7 | Bye | - | - |
| 8 | at Seahawks | Oct. 31 | 4:05 p.m. |
| 9 | vs. Bills | Nov. 7 | 1 p.m. |
| 10 | at Colts | Nov. 14 | 1 p.m. |
| 11 | vs. 49ers | Nov. 21 | 1 p.m. |
| 12 | vs. Falcons | Nov. 28 | 1 p.m. |
| 13 | at Rams | Dec. 5 | 4:25 p.m. |
| 14 | at Titans | Dec. 12 | 1 p.m. |
| 15 | vs. Texans | Dec. 19 | 1 p.m. |
| 16 | at Jets | Dec. 26 | 1 p.m. |
| 17 | at Patriots | Jan. 2 | 1 p.m. |
| 18 | vs. Colts | Jan. 9 | 1 p.m. |
