The NFL announced its complete 2021 regular-season schedule Wednesday. See below for matchups, dates, and start times for the Arizona Cardinals.
| Week | Opponent | Date | Time (ET) |
|---|---|---|---|
| 1 | at Titans | Sept. 12 | 1 p.m. |
| 2 | vs. Vikings | Sept. 19 | 4:05 p.m. |
| 3 | at Jaguars | Sept. 26 | 1 p.m. |
| 4 | at Rams | Oct. 3 | 4:05 p.m. |
| 5 | vs. 49ers | Oct. 10 | 4:25 p.m. |
| 6 | at Browns | Oct. 17 | 4:05 p.m. |
| 7 | vs. Texans | Oct. 24 | 4:25 p.m. |
| 8 | vs. Packers | Oct. 28 (TNF) | 8:20 p.m. |
| 9 | at 49ers | Nov. 7 | 4:25 p.m. |
| 10 | vs. Panthers | Nov. 14 | 4:05 p.m |
| 11 | at Seahawks | Nov. 21 | 4:25 p.m. |
| 12 | Bye | - | - |
| 13 | at Bears | Dec. 5 | 1 p.m. |
| 14 | vs. Rams | Dec. 13 (MNF) | 8:15 p.m. |
| 15 | at Lions | Dec. 19 | 1 p.m. |
| 16 | vs. Colts | Dec. 25 (Sat.) | 8:15 p.m. |
| 17 | at Cowboys | Jan. 2 | 1 p.m. |
| 18 | vs. Seahawks | Jan. 9 | 4:25 p.m. |
