Super Bowl odds: Bills favorites for 1st time after shootout win over Lions

Sunday's marquee game between the Bills and Lions had oddsmakers' full attention.

The Bills are now favored to win the Super Bowl after beating the Lions, who previously held the top spot on the oddsboard. Thanks to its 11th victory of the season, Buffalo's odds moved from +600 to +375 on theScore Bet/ESPN Bet.

The change in odds marks the Bills' first time being Super Bowl favorites this season.

The Lions fell from +225 to +450, tied with the Chiefs as third favorites. Not only did they lose to the Bills, but they also lost running back David Montgomery and defensive lineman Alim McNeill for the season, adding to the lengthy list of key injuries that already included star pass-rusher Aidan Hutchinson.

The Eagles, meanwhile, got closer to the NFC's No. 1 seed after dominating the Steelers to win their 10th straight game and improve to 12-2. Philadelphia has the NFL's leading rushing attack and is tied for the best scoring defense, giving it a legitimate claim as the league's most complete team. As a result, the Eagles have the second-best odds at +400 to hoist the Lombardi Trophy.

Detroit has the tiebreaker over Philadelphia, giving it the conference's top seed. But the Lions have tougher final three games than the Eagles, and their injury pileup could affect them down the stretch. They're currently +200 to win the NFC while the Eagles are +185.

In the AFC, the Bills' impressive win and eighth consecutive week scoring at least 30 points improved their Super Bowl chances with an implied probability of 21.1%. Buffalo (+185) also jumped Kansas City (+200) as the favorite to win the conference.

This is the first time this season K.C. is not at least the co-favorite to win the AFC. The Chiefs still hold the top seed at 13-1 while the Bills are 11-3, but the Chiefs' drop is as much about Patrick Mahomes' health as the Bills' recent success: Mahomes left Sunday's win over the Browns early with an ankle sprain. His status is uncertain, but the Chiefs are 2.5-point home underdogs against the Texans on Saturday, which indicates the star quarterback will likely sit. The Chiefs have three games in 11 days, so they'll likely be cautious with Mahomes over this tough stretch.

The Bills' win over the Lions influenced bettors to make a move: Over the past 24 hours, Buffalo has received the most Super Bowl bets and handle (money wagered). Almost half of the entire handle on the Super Bowl market has been on the Bills since Sunday morning.

Here are the Super Bowl odds for all playoff contenders.

The NFL's upper tier consists of the Bills, Chiefs, Lions, and Eagles. Any one of them could justifiably be the favorite, so expect the odds to continue to move in the season's final three weeks.

Sam Oshtry is a sports betting writer at theScore. You can follow him on X @soshtry for more betting coverage.