Week 10 of the NFL schedule is already underway. Sunday's slate kicks off with the final overseas game between the Lions and Patriots, and the Bengals host the Steelers on Sunday Night Football to cap the all-day action.
Here are our favorite picks against the spread, touchdown-scorer bets, and player props to target.
Jump to: Early slate | Late slate | Touchdown scorers | Player prop
👉 Check out all of the Week 10 lines available on theScore Bet here
Our trio of betting writers - Eric Patterson, Brenden Deeg, and Dane Belbeck - will make picks against the spread for Sunday's slate and Monday Night Football all season.
Eric Patterson breaks down his favorite picks against the spread, adding his own analysis and insights. He'll also identify touchdown scorers and player props to target.
🏈 Bet: Lions (-2.5)
The Lions and Patriots will square off in Munich this week. This line suggests Detroit would be roughly four-point favorites if this game were at Ford Field, which feels a tad short considering how both teams are playing. The Lions are on a four-game winning streak, and their defense is playing much better than it was at the start of the year. Meanwhile, the Patriots have lost two of their past three and failed to cover the spread in four straight weeks.
Even though the game isn't in a dome, I trust Jared Goff and his playmakers to score against the Patriots' defense, which has conceded 28.25 points per game since Week 6. Drake Maye has been doing everything he can to help the Patriots win, but New England's offense is devoid of talent, especially if A.J. Brown and Rhamondre Stevenson sit out.
🏈 Bet: Packers (-3)
The Packers dismantled the Patriots on the road last week. They have the league's 11th-best offense and, surprisingly, the sixth-best defense based on EPA/play, according to SumerSports. Despite its lack of a running game, Green Bay is one of the NFL's most balanced teams and is becoming increasingly difficult to beat.
While the Vikings' defense is the best unit in this game, Kirk Cousins can't be expected to fix all of Minnesota's offensive woes in only a few days. If the veteran quarterback had a couple of contests under his belt with his new team, Minnesota would be the side to take. However, it's difficult to trust the Vikings' offense to score enough to keep this game close.
🏈 Bet: Rams (-9.5)
Carson Beck will make his first NFL start against two of the greatest defensive players of all time. To make matters worse, Beck will play behind one of the league's worst offensive lines, which could be down to its third-string right tackle if seventh-round rookie Jayden Williams can't play. Myles Garrett and Aaron Donald dominated in the Rams' victory over the Commanders last week, and they should do the same against Arizona.
Though the Rams are down bodies on offense, they still have Kyren Williams and Blake Corum to rely on. Matthew Stafford has also made a career out of elevating his receivers, so Puka Nacua's absence shouldn't matter much against the Cardinals. If Stafford can score at least 20 points on Arizona's defense, I don't see how Beck can keep this one within nine points.
🏈 Bet: Steelers (+3.5)
Pittsburgh heads into its AFC North clash against Cincinnati with a huge rest advantage, as the Steelers had a bye in Week 10, while the Bengals played in Spain.
Beyond the rest, Pittsburgh's defense may be one of the few units that can slow down Joe Burrow, ranking seventh in EPA/play and ninth against the pass, according to SumerSports. The Steelers also boast one of the league's best rushing attacks - another potential matchup edge against a Bengals defense allowing the eighth-most yards on the ground per game (126.6).
Aaron Rodgers is doing a good job this season getting the ball to his best players on offense, and he should score enough points on Cincy to keep this game within a field goal.
Season-long record (9-16, -2.8% ROI)
🙌 Bet: Anytime TD (+120)
Tee Higgins has scored five touchdowns in the past three games. Burrow and the Bengals' passing attack are cooking, and nothing suggests that'll change against a Steelers defense that's elite at stopping the run. Burrow should throw at least two touchdowns, so +120 on Higgins is solid value.
🙌 Bet: To score 2+ TDs (+185)
The Cowboys have given up 13 touchdowns to opposing running backs this season, tied for second-most. Christian McCaffrey has three multi-score games in 2026, including two of the past three, when he and George Kittle have been the 49ers' only serious offensive weapons. Mike Evans won't be back for Week 10, giving McCaffrey more chances to score.
🙌 Bet: Anytime TD (+225)
The Lions surrender the most touchdowns to opposing tight ends, and Hunter Henry is one of the last pass-catchers still standing in New England. Assuming A.J. Brown is out, Henry - who has two touchdowns this season - will be one of Maye's few red-zone threats. Eli Raridon is also a solid option to score a touchdown at +325.
Season-long record (10-14, -17.3% ROI)
🏈 Bet: Over 7.5 receptions (+105)
Amon-Ra St. Brown will be a fan favorite this week in Munich, as the Lions' top receiver is half German. That reason alone isn't enough to trust him to catch eight passes, but you know he'll be extra motivated to put on a show for the German crowd.
St. Brown hasn't seen fewer than eight targets in a game this season and has caught eight-plus passes in five of eight outings. He's the focal point of the Lions' passing attack, and the Patriots are allowing the fifth-most receptions per game to opposing wide receivers. St. Brown will also avoid facing Christian Gonzalez for most of the game since he plays the majority of his snaps out of the slot.
🏈 Bet: Over 5.5 receptions (+105)
Matthew Golden has caught six-plus passes in five straight games and is averaging 12 targets per contest over his last four outings. The Packers' offensive attack is concentrated between Golden and Christian Watson, and it'll be even more so with Josh Jacobs sidelined. Expect another week of at least 10 targets for Golden, giving him a good chance to grab six more.
🏈 Bet: Over 1.5 receptions (+130)
Nacua has a 36.05% target share this season, and those targets have to go somewhere with him out of the lineup. Sure, L.A. may not throw it as often without Nacua and Davante Adams, but roughly 10 targets will be up for grabs against the Cardinals. Corum has seen at least two targets in five games this season, and he's one of the few explosive players healthy for the Rams. I'd expect Sean McVay to find creative ways to get the ball in Corum's hands.
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