49ers' Mitchell out vs. Bengals, Samuel listed as questionable

San Francisco 49ers running back Elijah Mitchell won't face the Cincinnati Bengals on Sunday due to a concussion and knee injury, according to Matt Maiocco of NBC Sports.

Mitchell tops the 49ers with 759 rushing yards and five scores on the ground through nine appearances this year. The sixth-round rookie also missed three games earlier this season due to multiple injuries.

The 49ers will likely rely on running backs Jeff Wilson and Jamycal Hasty with Mitchell sidelined. Rookie runner Trey Sermon was recently placed on injured reserve with an ankle ailment.

San Francisco is still hopeful that Deebo Samuel will be back in Week 14. The star wide receiver is listed as questionable after missing last week's loss to the Seattle Seahawks with a groin injury.

Samuel is having a career year in 2021, catching 56 passes for 1,001 yards and five touchdowns through the first 11 games. He's also had a big impact in the running game, finding the end zone five times.